The Role of P‐75 NGF‐R in the Diagnosis of Desmoplastic Melanoma
Identifieur interne : 008110 ( Main/Exploration ); précédent : 008109; suivant : 008111The Role of P‐75 NGF‐R in the Diagnosis of Desmoplastic Melanoma
Auteurs : S. Ghosn [États-Unis] ; A. Radfar [États-Unis] ; C. M. Stefanato [États-Unis] ; J. Bhawan [États-Unis]Source :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
The histologic diagnosis of desmoplastic melanoma is challenging, particularly when the overlying junctional component is absent and when the spindle cells lack melanin pigment. In these instances, the importance of immunohistochemistry cannot be overemphasized. S‐100 protein, with a sensitivity approaching 90%, is the primary immunohistochemical stain used for this purpose. HMB‐45, although a more specific marker for melanocytes, is often negative in these cases. A marker of schwannian differentiation, p‐75 NGF‐R has been shown to be a useful confirmatory marker for desmoplastic and neurotropic melanoma, with staining intensity comparable to or better than S‐100 protein. We report two cases of desmoplastic melanoma which stained focally and weakly with S‐100 protein in comparison with the stronger staining of p‐75 NGF‐R. In both cases, S‐100 staining could have been missed or interpreted as non‐confirmatory, thus misguiding the diagnosis. We therefore suggest that p‐75 NGF‐R be a complementary marker to S‐100 protein in differentiating desmoplastic melanoma from other non‐neural crest‐derived spindle cell tumors.
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DOI: 10.1111/j.0303-6987.2005.320cc.x
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Ghosn</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dermatopathology Section, Department of Dermatology, Boston University, School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Radfar, A" sort="Radfar, A" uniqKey="Radfar A" first="A." last="Radfar">A. Radfar</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dermatopathology Section, Department of Dermatology, Boston University, School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Stefanato, C M" sort="Stefanato, C M" uniqKey="Stefanato C" first="C. M." last="Stefanato">C. M. Stefanato</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dermatopathology Section, Department of Dermatology, Boston University, School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Bhawan, J" sort="Bhawan, J" uniqKey="Bhawan J" first="J." last="Bhawan">J. Bhawan</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dermatopathology Section, Department of Dermatology, Boston University, School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="89">89</biblScope><biblScope unit="page" to="89">89</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01">2005-01</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The histologic diagnosis of desmoplastic melanoma is challenging, particularly when the overlying junctional component is absent and when the spindle cells lack melanin pigment. In these instances, the importance of immunohistochemistry cannot be overemphasized. S‐100 protein, with a sensitivity approaching 90%, is the primary immunohistochemical stain used for this purpose. HMB‐45, although a more specific marker for melanocytes, is often negative in these cases. A marker of schwannian differentiation, p‐75 NGF‐R has been shown to be a useful confirmatory marker for desmoplastic and neurotropic melanoma, with staining intensity comparable to or better than S‐100 protein. We report two cases of desmoplastic melanoma which stained focally and weakly with S‐100 protein in comparison with the stronger staining of p‐75 NGF‐R. In both cases, S‐100 staining could have been missed or interpreted as non‐confirmatory, thus misguiding the diagnosis. We therefore suggest that p‐75 NGF‐R be a complementary marker to S‐100 protein in differentiating desmoplastic melanoma from other non‐neural crest‐derived spindle cell tumors.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Ghosn, S" sort="Ghosn, S" uniqKey="Ghosn S" first="S." last="Ghosn">S. Ghosn</name></region><name sortKey="Bhawan, J" sort="Bhawan, J" uniqKey="Bhawan J" first="J." last="Bhawan">J. Bhawan</name><name sortKey="Radfar, A" sort="Radfar, A" uniqKey="Radfar A" first="A." last="Radfar">A. Radfar</name><name sortKey="Stefanato, C M" sort="Stefanato, C M" uniqKey="Stefanato C" first="C. M." last="Stefanato">C. M. Stefanato</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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